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Curcumin-inducible HIF-1 degradation has been shown to impede the process of invasive metastasis in colorectal cancer cells by impeding glutamine catabolism through the inhibition of GLS1 and the suppression of EMT [66]

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Furthermore, nicotinamide adenine dinucleotide phosphate (NADPH), derived from niacin, is crucial in antioxidant defense mechanisms, by aiding in the regeneration of other antioxidants, such as glutathione (13)

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They resulted from various sources such as the over use of pesticides which contained heavy metals that potentially accumulate in the environment over time (Adeniyi et al