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10.1093/cvr/cvt091 178 SaravananG.PonmuruganP.SathiyavathiM.VadivukkarasiS.SengottuveluS

337 The MSU crystals are initially engulfed by macrophages, which then facilitate the assembly and activation of the NLRP3 inflammasome, preceded by priming through pathways that activate NF-B, such as those initiated by the engagement of Toll-like receptors (TLRs) within the TLR family

Degeneration of the lower motor neurons in the brainstem and spinal cord and the upper motor neurons in the motor cortex results in gradual denervation of voluntary muscles, leading to disruption of neural networks through a complex set of mechanisms eventually culminating in motor and non-motor symptoms (Table 2

However, the benefits have not been reproduced in clinical applications, this may be attributed to the limited absorption, concentration, and half-life of exogenous antioxidants

[SOURCED] Musculoskeletal and Tendon Models Staresinic et al