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Rating: 4.4428 (20 reviews)

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Description

Emerging role of glutathione peroxidase 4 in myeloid cell lineage development and acute myeloid leukemia

Luo Y, Tian G, Zhuang Z, Chen J, You N, Zhuo L, et al

R.RisbudM

One key limitation is the challenge of achieving a uniform electric field distribution throughout the sample, which can result in inconsistent cell permeabilization and variable extraction yields

Results: The core mechanism of MR lies in disrupting one-carbon metabolism and epigenetic regulation that rely on methionine, depleting the crucial metabolite S-adenosylmethionine (SAM), thereby inhibiting histone/DNA methylation, disrupting redox homeostasis, and ultimately inducing cell cycle arrest and apoptosis