glutathione peroxidase 1 slenium Proposed catalytic mechanism of peroxidase. Glutathione RCSB PDB - 1GP1: THE

Caffeine protects neurons from oxidative damage via increasing antioxidant enzymes, which reduce the production of reactive oxygen species (ROS) (155)

Furthermore, the levels of di- and tetra-oxygenated phosphatidylglycerol (PG) and PI species were increased in neuroblastoma tumor cells treated with withaferin A, a phytochemical that induces ferroptosis 16

Each row was individually analyzed without assuming a consistent SD

Curcumin analog ALZ003 can induce ubiquitination degradation of androgen receptor and significantly increase the sensitivity of GBM cells to temozolomide both in vitro and in vivo, and the mechanism may be related to ROS accumulation, lipid peroxidation and inhibition of GPX4, which are major features of ferroptosis

98 LinkA.BalaguerF.ShenY.LozanoJ