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Review of pramlintide as adjunctive therapy in treatment of type 1 and type 2 diabetes

Ghone RA, Kumbar KM, Suryakar AN, Katkam RV, Joshi NG

C., Bhutani, S., Hoddy, K

The forkhead transcription repressor FoxO1, involved in insulin signaling, is inactivated in absence of the late endosome/lysosome-anchored MARCH3, an E3 ubiquitin ligase, leading to changes in the expression of genes involved in vascular permeability [25]

Compared to the placebo group, those who received the silymarin saw a "significant decrease" in their levels of key diabetic markers hemoglobin A1C, fasting blood sugar, total cholesterol, low-density lipoprotein ("bad") cholesterol, and triglycerides.17 The second is a recent review published in the Annals of Hepatology in 2021, much of which relates to silymarin's effect on insulin resistance,18 a prominent marker for type 2 diabetes.19 Two of the studies referenced in the review were animal studies that administered 26.25-100mg/kg of silybin to rat subjects (equivalent to around 366-1,395mg for an 86kg, or 190lb, human) across 6-12 weeks