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Body composition is improved during 12 months treatment with metformin alone or combined with oral contraceptives compared with treatment with oral contraceptives in polycystic ovary syndrome

A typical model demonstrates the influence of the anti-ferroptotic defense system in mammalian cells, as described below in Section 5.1 [59] (Figure 4)

& Newland, A

Biochem Pharmacol 167:5863

Additionally, Nrf2 prevents OS, lowers osteoclast activation, and regulates periodontal cells growth, differentiation, and death to avoid periodontitis [13]