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Response: Although we acknowledge the applicant's concerns regarding the descriptor for C1739, we do not agree that the device category code should be withdrawn and replaced with a new code effective January 1, 2026, for the following reasons: First, per the applicant's request prior to CY 2026 rulemaking, CMS revised the descriptor for C1739 to read, effective October 1, 2025: Tissue marker, uniquely detectable and identifiable with probe/sensor, any method (implantable), with delivery system

Zinc and copper share common transport pathways, and increasing copper levels without adequate zinc can create functional deficiencies that impair immunity, wound healing, and hormone balance

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Thus, well-designed peptides and peptide derivatives can result in improved tumor treatment

Effect of a-lipoic acid on vitamin C and vitamin E deficiencies