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Although the anxiety and depression symptom instruments that were used have been validated, they are self-report questionnaires and only evaluated symptom severity, and they do not necessarily have diagnostic value

The orthopaedic surgeon or general practitioner may start symptom relieving medications until the patient has been assessed and referred to a rheumatologist Researchers are also working on biologic agents that can interrupt the progress of the disease

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[DOI] [PubMed] [Google Scholar] 24.Neiva R.F., Al-Shammari K., Wang H., Soehren S., Nociti F.H