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These intermediates can be further hydrolyzed, with the C 14 benzoyl ester bond being cleaved and one molecule of benzoic acid released, resulting in the formation of NDAs (e.g., aconine, mesaconine, and hypaconine)

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(Fig.4, Fig 5) Discussion With this study, the Neuropathic Pain Interest Group of the Italian Society of Neurology aimed to provide neurologists with practical guidelines for the treatment of fibromyalgia, a condition in which the involvement of the peripheral and central nervous system has been confirmed in several studies [2]