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A randomised, double-blind, placebo-controlled trial is the highest-quality study design for a single trial

The reasons are specific and addressable when identified early in the protocol

Discussion The mechanism by which IGF-1 production is regulated remains largely unknown 4

To help bypass any barriers to absorption in the GI tract, many healthcare providers recommend B12 injections for deficiency, but research shows that very high doses of oral B12 (1,000 to 2,000 mcg once a day) can normalize serum B12 levels to a similar extent with minimal side effects

It can spur cell growth to help regenerate damaged nerves and reduce chronic nerve pain