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Aung PP, Climent F, Muzzafar T, Curry JL, Patel KP, Servitje O, Prieto VG, Duvic M, Jaffe ES, Torres-Cabala CA

(2009) found that mutation of a Gpx to exchange the selenocysteine to cysteine at the catalytic site reduced the specific activity of the enzyme by two to three orders of magnitude