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Gupta and Chakrabarty, 2013

24] Commentary Circuit Judge Stoll disagreed with the majority of the CAFC, finding that the District Court had incorrectly applied the legal test for obviousness

By capturing molecular features such as aromaticity, hydrophobicity, charge, and hydrogen bond donor/acceptor properties, pharmacophore fingerprints enable the assessment of similarity between target binding sites, considering energy-minimized conformations of molecules to extract key pharmacophore features [101]

However, an important disadvantage of AMB is its high cytotoxicity, which may produce serious kidney and liver failure (Laniado-Laborin and Cabrales-Vargas, 3-bromopyruvate (3BP), a structural analog of a key cellular metabolite (pyruvate) is one of the most widely studied compounds from the group of halogenated carboxylic acids

PMID: 54 FarhanM.RizviA