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We subsequently revised 425.315 to apply the policies on reopening determinations to payment determinations for a 6-month performance year or 6-month performance period during CY 2019 (refer to the November 2018 final rule, 83 FR 59958 and 60092, and the December 2018 final rule, 83 FR 67955 through 67967), and to ACOs participating in the BASIC track (refer to the December 2018 final rule, 83 FR 67842 and 68068)

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This is a clinically important interaction that requires awareness, particularly in perioperative settings

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Although we typically associate NAC with acetaminophen toxicity, a prospective trial showed that NAC improved transplant-free survival in other etiologies of acute liver failure, most significantly in cases of DILI or HBV with coma grades I-II