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Methods: We performed whole-transcriptome sequencing (n=5) based on the liver tissues of responders (R) and non-responders (NR) from ten PBC/AIH OS patients

The ME of PBPs can be performed in different ways, including overexpression of PPs biosynthetic structural genes and transcription factors, up and down-regulation of genes/enzymes involved in the biosynthesis of certain PPs, silencing of specific metabolic routes in phenylpropanoid pathway, down-regulation of PPs biosynthesis structural genes using interference miRNAs, and enhancing the production of intermediary substrates of phenylpropanoid enzymes (365369)

A peer-reviewed study in the Journal of Endocrinology confirming that AOD9604 produces lipolysis and increases fat oxidation in obese mice via the beta-adrenergic pathway, with effects comparable to full-length HGH but without the insulin-disrupting side effects provided early mechanistic validation that informed the human trials