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Fitoterapia 83 , 12101217 (2012)

Its ability to activate autophagy, leading to increased angiogenesis, reduced apoptosis, and diminished oxidative stress, is particularly notable Trehalose stimulates the expression of Vascular Endothelial Growth Factor (VEGF) and cadherin 5, alongside an increase in MMP9 expression, thereby augmenting the viability of skin flaps

Notably, curcumin activates 5-adenosine monophosphate-activated protein kinase (AMPK) and inhibits mTOR (Zuo et al., 2021), remodels autophagy homeostasis to eliminate UV-induced damaged proteins, and regulates the Bcl-2/caspase-3 balance (Liu et al., 2018) and CD39/CD73-adenosine pathway (Manica et al., 2024), achieving a precise balance between anti-apoptosis and pro-repair

As a matter of fact, as a consequence of SIX1 down-modulation, glycolysis is reduced due to a decrease in glucose uptake, lactate and ATP production, extracellular acidification rate (ECAR) and an increase in oxygen consumption rate (OCR) [44]

Additionally, C-X-C chemokine ligand 12 (CXCL-12), also known as stromal cell-derived factor-1 (SDF-1), and C-X-C chemokine receptor type 4 (CXCR4) are chemokines responsible for facilitating the entry of bone marrow-derived cells (BMDC) into irradiated tissue [27]