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glutathione gbm6 patient derived xenograft Methionine cycle inhibition disrupts antioxidant metabolism and reduces glioblastoma cell survival Combined inhibition of de novo International Journal of Oncology Catabolism of extracellular glutathione supplies cysteine to support tumours Nature Redox Responsive Magnetic Nanoparticle for Targeted Convection Enhanced Delivery of O6 Benzylguanine to Brain Tumors ACS Nano Combined inhibition of de novo glutathione and nucleotide biosynthesis is synthetically lethal in glioblastoma ScienceDirect
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