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Description

Pathological hyperactivation of PI3K/AKT/mTOR signaling induces structural abnormalities including neuronal hypertrophy, axonal guidance defects, and disrupted connectivity patterns across brain regions (Heras-Sandoval et al., 2014)

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These distinct cellular attributes, coupled with their expression of immune recognition and effector molecules (see Table 1 ), form the structural foundation for their pivotal roles in immune function

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Finally, achieving reliable multimodal monitoring requires architectures capable of overcoming the large concentration disparity between millimolar metabolites and nanomolar signaling molecules [24,78]

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Several large meta-analyses found that alterations in KYN pathway metabolites were associated with mood, psychotic symptoms, and cognitive function in individuals with BD

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Author contributions KShig: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing original draft

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