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Some even lost up to 24% of their body weight

VEGF-targeted therapy: mechanisms of anti-tumour activity

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This suggesting that activation of the renal IGF-1 signaling may not be directly involved in the GH-induced pathological effects on the kidney.10,11 The mild glomerular changes observed, such as cell proliferation, could be mediated directly by renal IGF-1, since mesangial and other glomerular cells express the IGF1R.12 Interestingly, other studies have observed increased kidney weight following IGF-1 or GH administration in rats