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Conclusions Metabolism of estrogens via the catechol estrogen pathway is characterized by homeostasis, a balanced set of activating and protective enzymes (Fig

Studies using skin fibroblasts derived from such Fabry patient biopsies showed a reduced respiratory chain enzyme activity, along with a reduction of energy-rich phosphates AMP, ADP and CP, indicating an impaired mitochondrial energy supply and that this can play a role in the pathogenesis of Fabry disease through a proposed change in the properties of the mitochondria membrane [38], further implicating the mitochondrial dysfunction as part of the symptoms

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225 mg equiv