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Many plant-derived compounds act as natural ligands for nuclear receptors and transcription factors, including Nrf2, NF-B, and PPAR

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PMID: 34320814, DOI: 10.1161/strokeaha.121.034480

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Br J Pharmacol 180:24122435 Ji JL, Shi HM, Li ZL, Jin R, Qu GT, Zheng H, Wang E, Qiao YY, Li XY, Ding L et al (2023) Satellite cell-derived exosome-mediated delivery of microRNA-23a/27a/26a cluster ameliorates the renal tubulointerstitial fibrosis in mouse diabetic nephropathy

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This can be inhibited by mTORC2, leading to the suppression of apoptosis and support of autophagy [306]

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