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Additionally, studies indicate a weakening of the GSH/GPX4 antioxidant system in PD tissues

Cisplatin can down-regulate Nrf2 and HO-1 while upregulating inflammatory factors

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Further, while the mucolytic properties of NAC [85] may provide benefit to patients with chronic bronchitis, bronchiectasis or disorders of mucus clearance, particularly if prolonged mechanical ventilation is anticipated, this must be balanced with the potential for bronchospasm as discussed below

On the other hand, NPW treatment depressed the degree of lipid peroxidation, neutrophil infiltration and pro-inflammatory cytokine levels, and elevated antioxidant capacity in conjunction with the downregulation of gastric COX-1 and COX-2 mRNA levels, suggesting that improved gastric damage due to NPW could be eliminating the need for compensatory upregulation of COX enzymes