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Since prolyl 4-hydroxylation is, however, the single most prevalent post-translational modification in humans [33], we will focus on prolyl 4-hydroxylases within the present review

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It has been shown that PD-1 blockade for neoadjuvant therapy leads to the upregulation of T cells and IFN genes within the tumor and the reduction of the cell cycle in rGBM, thereby promoting anti-tumor responses [533]

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