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2010 Apr;56(3):290-9

L., Mitchell, D

Our later studies on the Shank3 -/- and Cntnap2 -/- knockout mice, the human SH-SY5Y cell line, and the human induced pluripotent stem cellsderived cortical neurons isolated from patients carrying a SHANK3 mutation confirmed the increased levels of NO and protein SNO [172,173,174,175,176]

Overexpression of NLGN2 in adult mice leads to increased localization of GABAergic synaptic proteins at presynaptic and postsynaptic sites, associated with deficits in hippocampus-dependent behaviors and memory formation (84)

Therefore, it is always necessary to start with a complete evaluation, including a physical exam of the scalp and hair, in addition to hormone and nutrient testing to address the underlying cause