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It appeared that sulofenur can undergo metabolic biotransformation to yield the GSH-conjugate of p -chlorophenyl isocyanate [ S -( N - p -chlorophenylcarbamoyl) GSH, SCPG

The activation of the immune system against gluten peptides begins after their transfer to the lamina propria where they are deamidated by the tissue transglutaminase enzyme and subsequently bounded to human leucocyte antigens (HLAs) expressed by antigen-presenting cells (APCs), which activate the inflammatory cascade (Figure 2) (239, 240)

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