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Introduction Parkinsons disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra par compacta (SNpc) and by impairments in motor function as well as other autonomic nervous system activities (Yamada et al., 2001

Regarding DML b (chr17: 34283701), ZNF136 (JASPAR ID: MA1588.1) can bind to the complementary region in the minus strand, but there is no evidence of its action on CCL11 expression

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While probiotics such as Bifidobacterium and Lactobacillus have shown potential in restoring gut microbial balance and modulating immune responses, their clinical application remains largely isolated, often lacking synergistic prebiotic supplementation (Ouyang et al., 2024)

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