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Long-term administration of nuclear bile acid receptor FXR agonist prevents spontaneous hepatocarcinogenesis in Abcb4(-/-) mice

[DOI] [PubMed] [Google Scholar] 99.Milyutina Y.P., Korenevskii A.V., Stepanov M.G., Arutyunyan A.V

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More importantly, we innovatively discovered that independent of its primary target, DNA-PKcs, KU-57788 binds to and activates DRP1, leading to excessive mitochondrial fission and activation of the NRF2/SLC7A11/GSH axis, thereby protecting ATC cells from ferroptosis

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