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For example, osteoporosis guidelines recommend a drug holiday (temporary discontinuation of therapy) from bisphosphonates depending on fracture risk after five years of treatment to mitigate risk of atypical femoral fractures and osteonecrosis of the jaw

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doi: 10.7554/eLife.63998 77 ShafiT.PoweN

In the VITdAL-ICU cohort, we analyzed 983 metabolites at Intensive Care Unit (ICU) admission, day 3, and 7