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In melanoma, the response to ICIs can be enhanced by using Smac mimetics which have a direct impact on immune cells such as B cells, MDSCs, DCs, and cytotoxic T cells (Michie et al., 2020)

In fact, AngII, via its AT 1 receptor, promotes cell growth, inflammation, vasoconstriction, apoptosis, production of extracellular matrix components and the release of ROS (198)

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