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Pathogenesis of NASH: the impact of multiple pathways

Most importantly, targeting either GSH with the inhibitor BSO or Nrf2 through an siRNA approach or with the small molecule inhibitor ML385 sensitised resistant MRT cells to cisplatin-induced cell death suggesting that targeting the Nrf2/GSH antioxidant defence pathway may present a novel therapeutic avenue in the design of new treatment strategies for MRT and a means of overcoming chemoresistance

Autism 7 , 37 (2016)

In this case, pump speed is increased accordingly, which in turn increases mechanical stress and causes cellular damage as well as further activation of the coagulation hierarchy

Similalry, significant improvement in the vitamin C content by the overexpression of some biosynthetic genes has been practically achieved in tomato, potato, lettuce and strawberry (Zhang et al., 2011