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Diabetologia 49(8):17111721 Rizzo G, Lagan AS (2020) A review of vitamin B12

[9] It is an option to explore for people carrying ApoE4 gene, which is a strong genetic risk factor for developing this condition

Especially smokers should thus avoid cyanocobalamin and use other forms of B12 instead this will keep their exposure to cyanide down, and will even help with detoxification