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Transfusion 56:421426

Unmetabolized acetone in the expired air accounted for 14.7, 5.3 and 25.2%, urinary excretion of acetone accounted for 1.4, 0.6 and 1.3%, respectively, and in vivo metabolism accounted for 83, 94.1 and 73%, respectively, of the radioactivity, Intravenous infusion of 2-[ 14 C]-acetone into patients with diabetic ketoacidosis resulted in a mean plasma acetone turnover rate of 6.45 mol/kg/min (Reichard et al., 1986)

The FDA applied a four-part statutory test under 21 CFR 216.23(c): physical and chemical characterization, historical compounding use, evidence of effectiveness, and safety

This mechanism has been deeply studied in other psychiatric disorders like MDD [146]