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Some important modifications and their significance are summarized in the table below: Table 1: Peptide modifications and their significance

the structure (and sequence) can be optimized for increased protein stability outside the expressing cell, until the time when it is recognized by immune cells, including APCs

17-week old, male DIO C57Bl/6 mice that have been fed high-fat diet (HFD) for 11 weeks (starting at week 6) were purchased from Jackson Labs (Jackson Laboratory

Tested antibody or ADC was conjugated to APC fluorophore using LYNX Rapid APC Antibody Conjugation Kit according to the manufacturers protocol (Bio-Rad, Cat#LNK032APC)

Transmission risk increases 2- to 3-fold if the HCV infected mother also has human immunodeficiency virus (HIV)