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Meanwhile, ATP rapidly degrades to adenosine through pathways such as PI3K/Akt and MEK/ERK to regulate macrophage proliferation and induce adenosine accumulation to promote immune suppression (154)

We direct the reader to other excellent reviews for more detailed explanations on these processes [13, 16, 17]

In the present investigation, the reduced activity of ALT and AST enzymes and creatinine levels in T1_HS and T2_HS groups may be attributed to the enhanced antioxidant enzyme activity (GPx, SOD, catalase) and lower MDA levels in these groups 7,11

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Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 20072017