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Findings are experimental and observational

OS was shown to be associated to a varying extend with many reproductive diseases such as the PCOS (129), unexplained infertility (122) and even RM ( Figure 1 )

[DOI] [PMC free article] [PubMed] [Google Scholar] 2.Newman AC, Maddocks OD

Importantly, this effect was mitigated in cells overexpressing Bcl-2, underlining the role of the mitochondrial pathway

Overexpression of IRP2 or MPP + treatment significantly enhances the binding of IRP2 to p53 in PC-12 cells, upregulates p53 levels, downregulates SLC7A11 expression, and increases arachidonate 12-Lipoxygenase (ALOX12) expression, thereby promoting ferroptosis and amino acid antioxidant system disruptions, elevating MDA levels, and inducing PC-12 cell damage