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Several drugs have been identified to target Ca v for treating neuropathic pain and exhibit high efficacy in pre-clinical chronic pain study (Patel et al., 2018)

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Future studies utilizing lineage tracing approachessuch as Cd11c -Cre/ t dTomato reporter micecombined with single-cell technologies (e.g., single-cell RNA sequencing) will be valuable for identifying the specific cell populations responsible for promoting liver injury under conditions of iron overload