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6 Conclusion and perspective Ferroptosis, an irondependent, lipid peroxidationdriven form of regulated cell death, has emerged as a key pathophysiological mechanism in IPF, linking alveolar epithelial injury to persistent inflammation, macrophage activation, and fibrotic remodeling of the lung parenchyma (177)

Most patients describe the sensation as a quick pinch with minimal discomfort

Nevertheless, in patients who were not on any treatment, 400 mg/day of sulbutiamine did not show any improvement [31]