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The ER also communicates with mitochondria via signaling from the unfolded protein response (UPR), which is activated by ER stress and signals through the three ER-resident stress sensors IRE1, PERK, and ATF6 (Walter and Ron, 2011)

No major diet-related toxicities necessitating discontinuation were reported, reinforcing earlier observations that KD can be safely integrated into supportive cancer care under medical supervision