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Statements Author contributions All authors contributed to concept development

ROS mutate genes involved in various metabolic pathways throughout the body and prevent the detoxification and excretion of toxic waste

Recently we reported that the AT4 receptor antagonist Norleual- AngIV (Nle-YI--(CH2-NH2)-HPF) inhibited HGF binding to c-Met and in turn HGF-dependent signaling, proliferation, invasion, and scattering [78]