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Cancer cells exhibit an iron-seeking phenotype by upregulating iron-related proteins (TFR1, STEAP, DMT1, hepcidin, SLC39A14) and downregulating FPN, thereby promoting iron uptake and accumulation (59)

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eubiosis), intestinal barrier integrity, systemic inflammation, insulin resistance, dyslipidemia, adipose tissue accumulation, and immune cell responses (TLR4, TLR2, Treg, Th1, Th2, Th17), culminating in adverse obesity rather than a healthy metabolic condition