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This region includes tumor suppressor genes, CDKN2A which encodes for CDK4 and CDK6 inhibitor p16 INK4A and ARF encoding p14 which is a stabilizer of p53

Cell Death Differ 15:18571864 Nurdiani R, Vasiljevic T, Singh TK, Donkor ON, Prihanto AA, Kusuma TS (2022) Stability of an anticancer peptide isolated from Flathead by-products during in vitro gastrointestinal digestion

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Notably, the crystal structure revealed that the G-loop gate and inner helix gate are too constricted to conduct hydrated K + ions, suggesting the channel in the presence of PIP 2 is closed in this structure (Whorton and MacKinnon, 2011)

The absorbance at 532 nm was subtracted from the one obtained at 600 nm, and the amount of MDA was calculated using an extinction coefficient of 155 mM -1 cm -1