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two brothers, Claude Joseph Buirse and Joe Brayden

Cell 187 (12), 29002902 (2024)

The NAPQI causes cell injury and death resulting in the hepatic necrosis seen with acetaminophen overdose, which can result in liver failure and death

At the same time, E GABA also depends on [Cl] in the synaptic cleft, which is regulated by astrocytic Cl transport mechanisms and astrocytic Cl release