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The authors suggest that alterations in the synchronization and amplitude of luteinizing hormone peaks induced by estradiol during the transition to infertility in middle age could be triggering these changes (Wise et al., 1988)

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3.3 Pyroptosis pathway Depending on whether pyroptosis requires caspase-1 activation, it can be divided into the classical and non-classical inflammasome pathways ( Figure 5 )

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All reagents except the extract or standard were included in the blank, with 0.1 mL of water used in place of the sample