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Abbreviations ALI: Acute lung injury DM: Diabetes mellitus AGEs: Advanced glycation end products LPS: Lipopolysaccharide DEGs: Differentially expressed genes BEAS-2B: Bronchial epithelial cells AMPK: AMP-activated protein kinase MDA: Malondialdehyde GPX4: Glutathione peroxidase 4 SLC7A11: Solute carrier family 7 member 11 ACC: Acetyl-CoA carboxylase ARDS: Acute respiratory distress syndrome FBG: Fasting blood glucose CRP: C-reactive protein PCT: Procalcitonin WBC: White blood cell IL-6: Interleukin-6 GEO: Gene Expression Omnibus KEGG: Kyoto Encyclopedia of Genes and Genomes GO: Gene Ontology HFD: High-fat diet ACSL4: Acyl-CoA synthetase long chain family member 4 LPCAT3: Lysophosphatidylcholine acyltransferase 3 LOX: Lipoxygenases PUFAs: Polyunsaturated fatty acids References Ferguson, N

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Protein phosphorylation acts as an essential signal relay mechanism in bacteria (and other domains of life) as it manages the on and off switching of proteins (Garcia-Garcia et al., 2016)

The exceptional importance of reduced glutathione is to protect cells from damage