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DMSO is itself a known skin irritant and penetration enhancer, so community sources often attribute these reactions to the carrier as much as to Dihexa

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Patients with HS have a higher risk of developing depression, and have reported higher depression scores than their matched controls

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Signs of a severe allergic reaction (anaphylaxis) include: Skin rash, hives, or severe itching Swelling of the face, lips, tongue, or throat Difficulty breathing or wheezing A rapid heartbeat or a sudden drop in blood pressure If you ever develop swelling of the face or throat, trouble breathing, or other signs of a severe reaction after any injection, treat it as an emergency and call 911