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The risk is greatest among infants who are fed formula low in biotin, people taking antiepileptic medications, infants with Leiners disease or people who are genetically predisposed to deficiency ( Untreated biotin deficiency can cause neurological symptoms, such as seizures, intellectual disability and loss of muscle coordination ( Deficiency has also been reported in animals fed high amounts of raw egg whites

These autoantibodies are hypothesised to target nuclear, membrane, and neurotransmitter receptor structures (255)

doi: 10.1038/s41581-024-00820-6 3 Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group

Exclusion criteria included non-rodent species, animal models centered on general neurological or psychiatric conditions not specific to ASD, and non-pharmacological or non-gut microbiota interventions (behavioral, dietary, device, surgical, herbal only)

Because the liver is either a source or sink for accumulation of heme precursors, or porphyrins, we investigated the role of Wnt/beta-catenin signaling, a pathway that contributes to unique hepatic attributes such as zonation, autophagy, and metabolic regulation