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Such metabolic disorders can initiate a cascade of events, including the dysregulation of the tricarboxylic acid cycle (TCA), which is integral to the oxidative phosphorylation processes in cardiac myocytes (6)

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Notably, a recent study demonstrated that Ganoderic acid D overcomes gemcitabine resistance by promoting the degradation of HIF-1 driven by MDM2, which leads to a reduction in glycolysis in triple-negative breast cancer cells (Luo et al., 2024)

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Sell NM, Cassidy DJ, McKinley SK, Petrusa E, Gee DW, Antonoff MB , Phitayakorn R