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Defining the correlation between immune-checkpoint inhibitors-related adverse events and clinical outcomes: a narrative review Omar Abdihamid 1 , Abeid Omar 2 and Tibera Rugambwa 3 1 Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, Peoples Republic of China 2 Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Alexandria University, Champlion Street, Alazarita, Alexandria 21131, Egypt 3 Department of Internal Medicine, Mbeya Zonal Referral Hospital, Mbeya 419, Tanzania Abstract Immune checkpoint inhibitors (ICIs) have increased modern anticancer armamentarium portfolios, with 15%60% of cancer patients deriving clinical benefit while others progress, including some occurrences of accelerated progressions

In addition, supplementation with lutein and zeaxanthin has been very effective at restoring these important ocular antioxidants [12, 13]

diluted at 1:1,000) were all identified by the antibodies used (Sigma-Aldrich, United States)

Proper cycling, intelligent stacking, and careful source vetting are critical

Provides neuroprotective activity by supporting dopaminergic and serotonergic signaling