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The isolated effector domain exists primarily as a monomer in solution, but forms a hexamer ring in crystal via tandem association between adjacent protomers, and two hexamers are linked by the crystallographic 2-fold symmetry to generate a dodecamer [323]

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Ogasawara, R., et al

doi: 10.1002/hep.31288 18 SankarKGongJOsipovAMilesSAKosariKNissenNNet al