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This spatial and functional plasticity is essential for maintaining synaptic transmission, neuronal excitability and overall neurophysiological stability

This disruption leads to accumulation of neurotoxic and/or phototoxic haem precursors, and so these conditions are characterised by acute neurological and visceral symptoms ('neurovisceral crises') and/or skin lesions

Stranded mRNA-seq libraries were prepared using the NEBNext Ultra II RNA library Prep Kit for Illumina (New England Biolabs, NEB #E7770)

1147 Enhanced lipid peroxidation, which leads to vascular membrane damage, is central to cardiovascular disease mechanisms

This suggests that GPX2 deficiency leads to specific cellular stress responses during endoderm differentiation