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Subsequent mutational analysis of a Drosophila GPx ( Dm GPx) also suggests a function for a conserved Asn residue that is necessary for the enzymatic function of the GPxs (361)

Br J Nutr 110(8):13571368

J Cell Sci 117:25912598 Acknowledgements RKT is grateful to DST SERB, New Delhi, for Teachers Associateship for Research Excellence (TAR/2019/000064)

Inhibition of the Xc- transport system by genetic (siRNA, CRISPR) or pharmacological means (Erastin, Sulfasalazine) impairs cystine transport and GSH synthesis, leading to the inactivation of GPX4 and induction of ferroptosis [14]

OCSCs drive the polarization of macrophages into an immunosuppressive M2-like phenotype, characterized by increased CD206 expression, via the secretion of WNT ligands and cytokines like IL-10